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MLL innovation services is dedicated to the digital processing of data from leukemia diagnostics. MLLi provides scientists, researchers, doctors, and biologists with browser-based tools for the interpretation of molecular data for hematological diagnoses.
Digital Services
MLLi:db (data base)
Variant classification & annotation / Retrace with additional databases / MLL AI prediction score / Interactive search / Variant specific report
MLLi:ir (interpretation report)
Manual expert curation service / Raw NGS data to diagnostics statements / Personalized medical report / Variant classification & annotation / No bioinformatics expertise needed
Knowledgebase
Every day we are faced with the challenge of correctly interpreting changes detected by Next generation sequencing (NGS) in order to make the right diagnosis for the patient and to open up the best possible therapy options based on the mutational profile. In addition to the laboratory database, public databases are available, which are often the only helpful sources of information. With the project MLLi:db ("db" for "database"), we anonymously publish manually curated data collected over the past 12 years from the sequencing of diagnostic samples in an ISO 15189 accredited environment, adding with that another source of information for variant interpretation. Since we are specialized on hematology our database MLLi:db covers variants, that are so far under-represented in public databases.
Web application: for variant interpretation of NGS data
Classification: Each variant in MLLi:db is labelled according to a 3-tier classification system: mutated, variant of unknown significance, benign
Quality: Manually curated variants, resolve potential discrepancies from other databases
Annotation: In addition to the lab’s own data we provide convenient access to the following sources for many variants: COSMIC, dbSNP, gnomAD, CiinVar, dbNSFP
Notification: Notification system, if classification changes over time
Pathogenicity: MLL Predictor (automated consensus classification based on 14 sources)
VCF File: Optimize variant querying by uploading a VCF file containing the complete batch of variants detected in a sample and receive classification of those variants with matches in MLLi:db
14 different leukemia and lymphoma types are represented, with 200 to >14,000 individuals per entity
currently 1,211 pathogen variants, 477 benign, and 44 variants of unknown significance are represented
39% missense variants, 19% nonsense variants, 16% frame-shift variants, 18% synonymous variants, 6% splice site variants, and 2% in-frame variants are covered
Coding change
Protein change
Variant allele frequency
Genetic location
Type of mutation/variant
Variant interpretation/classification
MLL predictor score
Disease entity distribution
Frequency of positive individuals
232539
unique samples
104
genes of query
1732
unique variants
4
eyes-principle
Demo sign in and report
Free demo
Register to have a free trial of the interactive web application MLLi:db database. 10 variants are completely free to explore, as well as tools such as an interactive genome browser (IGV), genome coordinates converter and a display for the frequencies of mutations in genes.
Demo report
Download an example PDF for a variant from the MLLi:db database. Convenient for printing or attaching to a patient file. Clearly laid out with a summary at the beginning and with an explanatory text for each database.
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Your contact person
»Artificial intelligence will enable medicine to evolve rapidly.«
Niroshan Nadarajah
Bioinformatician, M.Sc.
Innovation & Partner Management
Deputy Head of Research
niroshan.nadarajah@mll.com