Articles

  • Dr. med. Christian Pohlkamp
    from 08.06.2020
    Identifying resistance mutations in targeted therapies

    Over the past few years, the use of targeted therapies has proven effective for various forms of hematological neoplasia, and increasingly become routine. The rational molecular design of such active substances allows for the targeted blocking of intracellular signal chains in malignant cells, resulting e.g. in cell cycle arrest or ideally apoptosis. Unfortunately, resistance occurs even against such tailored therapies.

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  • Dr. rer. nat. Constance Bär
    from 18.02.2020
    Assessing Sequence Variants

    Sequencing technologies have developed rapidly in the last few years. It is possible to sequence an entire genome or a larger panel within just a few days. At the MLL, data from the sequencing machine is loaded to our private cloud in real time and automatically preprocessed using the very latest algorithms.

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  • Dr. rer. nat. Sabine Jeromin
    from 16.11.2019
    Standardization of the BCR-ABL1 Quantification in CML

    When using molecular tests to quantify BCR-ABL1 in CML patients, it is recommended that the test be performed in a standardized laboratory. Standardization ensures that results comply with the ELN (European LeukemiaNet; Baccarani et al., Blood 2013) guidelines, enables comparisons to be made between laboratories and serves as quality assurance.

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  • from 05.11.2019
    Immunophenotyping in multiple myeloma: Patients without minimal residual disease live longer

    The prognostic significance of minimal residual disease (MRD) in patients with multiple myeloma has been examined in numerous studies and is the subject of much controversial discussion. Existing data has to date been extremely heterogeneous with regard to patient collectives, therapies, number of cases, and the methodology via which MRD was detected.

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  • from 01.11.2019
    Additional molecular genetic diagnostics for multiple myeloma

    Approx. 10% of all hematological neoplasias are plasma cell diseases such as multiple myeloma (MM) or plasma cell leukemias. As is the case for other hematological diseases, molecular genetic diagnostics can be viewed as increasingly relevant in the diagnosis, prognosis and therapeutic stratification of MM.

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  • Dr. med. Christian Pohlkamp
    from 30.10.2019
    Munich Leukemia Laboratory MLL offers integrated findings for myelodysplastic syndromes

    After the successful introduction of Integrated Findings for acute myeloid leukemia (AML) at the end of 2017, Münchner Leukämielabor GmbH (MLL) now also offers a version for myelodysplastic syndromes (MDS). The goal here is also to provide both a clear summary and detailed interpretation of the often complex constellation of individual cytomorphological, flow cytometry, and in particular cytogenetic and molecular genetic findings.

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  • Dr. med. Christian Pohlkamp
    from 28.10.2019
    Step-by-step diagnosis at MLL

    Cost-conscious diagnostics are a must. As MLL hematologists who, in general, have invariably spent a lot of time working in hospitals and outpatient clinics, we are particularly aware of this problem. It has thus always been our priority to provide you and your patients with a cost-effective procedure in the form of step-by-step diagnostics.

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  • Dr. rer. nat. Ines Schmidts
    from 23.10.2019
    The importance of advanced molecular diagnostics in cytopenia and (suspected) MDS

    Next-generation sequencing (NGS) has rapidly become an indispensable tool in diagnostic molecular genetics. A recent article in Blood (Steensma Blood 2018) examined how patients with ambiguous cytopenia or with a (suspected) MDS diagnosis can benefit from the diagnostic potential of NGS.

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  • Dr. rer. nat. Ines Schmidts
    from 17.10.2019
    The importance of next-generation sequencing (NGS) diagnostics in (suspected) acute myeloid leukemia (AML)

    In the last issue (1/2019), MLL News featured an article which was recently published in Blood on the use of high-throughput sequencing in (unclear) cytopenia and MDS (Steensma et al. 2018). Next-generation sequencing (NGS) is already playing a major role in AML diagnostics today and will continue to become more and more important.

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